How about ending up with no one? Not every anime character has to be with someone just because they were with them alot. Maybe Inu Yasha will end up dying?...
No, they don't do that to main characters. Well, obviously, if InuYasha were to end up with somebody, it will most likely be Kagome, because I've been watching it to episode 75, and it sounds like Inu Yasha and Kagome both have feeings for eachother, but don't say anything.
This is just my opinion.
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